An intensive survey of molluscan associations with coral reef and sedimentary facies in Safaga Bay, Northern Red Sea, revealed a number of taxa either new to the Red Sea or new to science. Species new to science belong to the genera: Limopsis (Limopsidae); Semelangulus (Tellinidae) and Abra (Semelidae). Species recorded for the first time from the Red Sea are: Ctenoides concentrica (Limidae); Codakia paytenorum (Lucinidae); Leptomyaria etesiaca (Semelidae) and Costellipitar chordatum (Veneridae). The genus Offadesma (Periplomatidae) is recorded but from a single valve only, which is of uncertain species status. Ventricolaria toreuma (Veneridae) is confirmed to be of frequent occurrence following its first recorded presence in 1995.